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Updated: 2003-09-29 01:00

Man's best friend, genetically more like him than a mouse
狗——人類最親密的朋友

Dogs are genetically closer to man than mice, US researchers said, detailing a partial sequencing of the dog genome.

The researchers at the Institute for Genomic Research and the Center for the Advancement of Genomics assembled 6.22 million sequences of dog DNA for nearly 80 percent coverage of the genome, they said in a statement.

"Comparing the dog sequence data with current drafts of the human and mouse genome sequences showed that the dog lineage was the first to diverge from the common ancestor of the three species, and that the human and dog are much more similar to each other at the genetic level than to the mouse," they said in results published in the review Science.

The project found that more than 25 percent, or 650 million base pairs, of DNA overlap between human and dog.

"The sequence data was used to identify an equivalent dog gene for 75 percent of known human genes," they added.

"In little more than a decade, genomics has advanced greatly and we now have approximately 150 completed genomes including the human, mouse and fruit fly, in the public domain," said Craig Venter, president of the TCAG.

"Our new method is an efficient and effective way of sequencing that will allow more organisms to be analyzed while still providing significant information."

(Agencies)

美國研究者稱,他們仔細研究了狗的基因組部分序列,認為從遺傳角度講狗比老鼠更接近人類。

基因組研究所和先進基因體學研究中心的研究者們在報告中說他們搜集了622萬組狗的DNA序列,囊括了接近80%的基因組。

他們在《科學》雜志上發表的結果中提到:“通過比較狗基因組序列數據和現有的人類基因組草圖以及老鼠的基因組序列,結果顯示狗類家族首先從三者共同的祖先中分離出來,在遺傳等級上狗比老鼠更接近人類,與人類更相似。”

該研究發現人類和狗互相重合的DNA超過25%,相當于6.5億鹼基對。

他們還說:“序列數據被用來確認與75%的已知人類基因相對應的狗的基因。”

先進基因體學研究中心主任克雷格·文特爾說“在近十年里,基因體學發展迅速,我們在開放的領域里已經有大約150組完整的基因組,包括人類,老鼠和果蠅。”

“我們的新排序方法既經濟又有效,能夠分析更多的生物體,提供重要的信息。”

(中國日報網站譯)

 
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